Indicated for: urinary stones; urinary alkalinization
Route of administration: oral
Substance: potassium sodium hydrogen citrate (citrate urinary alkalinizer)
ATC: G04BCN1 (Genito urinary system and sex hormones | Urologicals | Urinary concrement solvents)
Do not take with milk, calcium, iron, magnesium, or antacids if separation is recommended.
This medicine may change blood electrolyte levels.
Potassium sodium hydrogen citrate is a urinary alkalinising agent used to increase urine pH. It is mainly used to dissolve or prevent certain urinary stones, especially uric acid stones, and sometimes to reduce urinary acidity in selected situations. It is not suitable for every type of kidney stone and should be guided by diagnosis.
It is taken by mouth, usually as granules or solution dissolved in water, according to the recommended dose. Treatment often requires measuring urine pH with indicator paper and dose adjustment by the doctor. Fluid intake, diet and analysis of the stone type are important. Do not increase the dose without advice, because urine that is too alkaline may promote other stones.
Side effects may include stomach discomfort, nausea, diarrhoea, bloating or fullness. Because it contains potassium and sodium, caution is needed in patients with kidney disease, heart failure, high blood pressure, oedema or medicines that increase potassium, such as ACE inhibitors, sartans, spironolactone or potassium supplements.
Contact a doctor if marked weakness, palpitations, confusion, cramps, major swelling, reduced urination, severe flank pain, fever or blood in the urine occurs. Blood tests may be needed to monitor electrolytes and kidney function. Treatment is useful only when adapted to the stone type and monitored properly.