Leaflet OSVAREN 435mg / 235mg film-coated tablets


Indicated for: hyperphosphatemia

Route of administration: oral

Substance: calcium acetate + magnesium subcarbonate (mineral phosphate binders)

ATC: V03AE04 (Various | All other therapeutic products | Drugs for treatment of hyperkalemia and hyperphosphatemia)

The combination of calcii acetas and magnesii subcarbonas is used for the treatment of hyperphosphatemia in patients with chronic kidney disease, particularly those on dialysis. These phosphate binders reduce the absorption of phosphate from food, helping to maintain an appropriate phosphorus balance in the body and preventing complications associated with high phosphate levels, such as vascular calcifications.

The medication is taken orally, usually during meals, as directed by a doctor. The dosage is adjusted based on serum phosphate levels and the patient's response to treatment.

Common side effects include nausea, constipation, diarrhea, and abdominal discomfort. In rare cases, more severe adverse effects such as hypercalcemia or hypermagnesemia may occur, requiring dose adjustment or discontinuation of treatment.

This combination is not recommended for pregnant or breastfeeding women unless the benefits outweigh the risks. Patients should inform their doctor about all medications and supplements they are taking to avoid drug interactions. Additionally, regular monitoring is important to prevent complications associated with mineral imbalances.

General data about OSVAREN 435mg / 235mg

  • Substance: calcium acetate + magnesium subcarbonate
  • Date of last drug list: 01-05-2026
  • Commercial code: W59601001
  • Concentration: 435mg / 235mg
  • Pharmaceutical form: film-coated tablets
  • Quantity: 180
  • Product type: generic
  • Price: 107.69 RON
  • Prescription restrictions: P-6L - Medicines prescription that isn't retained in the pharmacy (can be renewed); the prescription can be used for 6 months from the moment of release.

Marketing authorisation

  • Manufacturer: FRESENIUS MEDICAL CARE NEPHROLOGICA DEUTSCHLAND GM - GERMANIA
  • Holder: FRESENIUS MEDICAL CARE NEPHROLOGICA DEUTSCHLAND GM - GERMANIA
  • Number: 10963/2018/01
  • Shelf life: 3 years-after packing for marketing; after the first opening-3 months