Leaflet NOBIXAL 12.5mg film-coated tablets

Indicated for: depression

Route of administration: oral

Substance: tianeptine (antidepressant)

ATC: N06AX14 (Nervous system | Antidepressants | Other antidepressants)

Precautions:
Driving impairment
Driving impairment

This medicine may affect your ability to drive or use machines.

Dizziness / vertigo
Dizziness / vertigo

This medicine may cause dizziness or vertigo.

Breastfeeding warning
Breastfeeding warning

Use during breastfeeding only on medical advice.

Pregnancy warning
Pregnancy warning

Use during pregnancy only on medical advice.

Suicidal ideation / mental changes
Suicidal ideation / mental changes

Seek medical help if suicidal thoughts or major behavior changes occur.

Withdrawal / do not stop abruptly
Withdrawal / do not stop abruptly

Do not stop treatment abruptly without medical advice.

Drowsiness / sedation
Drowsiness / sedation

This medicine may cause drowsiness or reduced alertness.

Tianeptine is a medication primarily used for the treatment of major depressive disorder, but it also has benefits in managing anxiety and post-traumatic stress disorder (PTSD). It is an atypical antidepressant that works differently from other classes of antidepressants by modulating glutamate activity and increasing serotonin reuptake in the brain, without directly affecting serotonin receptors.

Tianeptine also has neuroprotective properties and can enhance neuroplasticity, which helps reduce depressive symptoms and improve cognitive function. It is taken orally, usually 2-3 times per day, as prescribed by a doctor.

Common side effects include nausea, drowsiness, dizziness, dry mouth, and constipation. In rare cases, it may cause dependence, especially at high doses or with misuse. For this reason, tianeptine use should be carefully monitored, and it is contraindicated in patients with a history of substance abuse.

General data about NOBIXAL 12.5mg

  • Substance: tianeptine
  • Date of latest medicines list: 01-06-2026
  • Product code: W60648008
  • Concentration: 12.5mg
  • Pharmaceutical form: film-coated tablets
  • Quantity: 30
  • Product type: Generic medicine
  • Price: 18.04 RON
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: ANTIBIOTICE S.A. - MAREA BRITANIE
  • Holder: ANTIBIOTICE S.A. - ROMANIA
  • Number: 10296/2017/08
  • Shelf life: 2 years

Pharmaceutical forms available for tianeptine

Compensation lists for NOBIXAL 12.5mg Antibiotice

B - Sublist B with 50% discount from the reference price

Price

Copayment

Patient

18.04 RON

9.02 RON

9.02 RON

G15 (C1) - Mental disorders

Price

Copayment

Patient

18.04 RON

18.04 RON

0.00 RON

GX (C1) - GENERIC (used in compensation list, C1, for another diagnosis)

Price

Copayment

Patient

18.04 RON

18.04 RON

0.00 RON