Medication leaflets

Active substance

Results for the substance agomelatine

3 results

About this active substance

Agomelatine is a medication used to treat major depressive disorder in adults. It works by regulating the circadian rhythm and serotonin levels, providing benefits for sleep and mood. It is an agonist of melatonin receptors (MT1 and MT2) and an antagonist of serotonin 5-HT2C receptors, which helps improve depressive symptoms.

One advantage of agomelatine is that it does not affect sexual function and has a low risk of causing weight gain compared to other antidepressants. It also helps restore normal sleep patterns without having a sedative effect.

Side effects may include nausea, dizziness, headache, or fatigue. In rare cases, it can affect liver function, so regular monitoring of liver enzymes is required during treatment. It is contraindicated in patients with severe liver conditions. The medication should be taken as prescribed by a doctor, usually once daily in the evening.