Active substance
Results for the substance donidalorsen
1 result
About this active substance
Donidalorsen prevents hereditary angioedema attacks in adults and adolescents aged 12 years and over. It is an antisense oligonucleotide that reduces production of prekallikrein in the liver. This limits formation of bradykinin, a substance involved in swelling of the skin, abdomen or airways.
It is injected under the skin, usually once every 4 weeks; the doctor may choose an 8-week interval for some patients. After training, patients or caregivers can give the injection. It does not treat an attack that has already started: keep on-demand treatment available and follow the specialist's emergency plan.
Possible side effects include pain, redness, itching or bruising at the injection site, respiratory infections, urinary tract infections and abdominal discomfort. Severe allergic reactions, including anaphylaxis, have been reported. The doctor may monitor liver tests and platelet counts because these values can change.
Tongue or throat swelling, breathing difficulty, widespread hives or faintness requires immediate help; a throat attack remains an emergency despite preventive treatment. Tell the doctor about pregnancy, breastfeeding, liver or kidney disease and previous allergies. Record attacks between doses so treatment effectiveness can be assessed, and do not change the dosing interval yourself.
It is injected under the skin, usually once every 4 weeks; the doctor may choose an 8-week interval for some patients. After training, patients or caregivers can give the injection. It does not treat an attack that has already started: keep on-demand treatment available and follow the specialist's emergency plan.
Possible side effects include pain, redness, itching or bruising at the injection site, respiratory infections, urinary tract infections and abdominal discomfort. Severe allergic reactions, including anaphylaxis, have been reported. The doctor may monitor liver tests and platelet counts because these values can change.
Tongue or throat swelling, breathing difficulty, widespread hives or faintness requires immediate help; a throat attack remains an emergency despite preventive treatment. Tell the doctor about pregnancy, breastfeeding, liver or kidney disease and previous allergies. Record attacks between doses so treatment effectiveness can be assessed, and do not change the dosing interval yourself.