Results for the substance acemetacin

Acemetacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with rheumatic and musculoskeletal conditions. It is a derivative of indomethacin but has better gastrointestinal tolerability. Acemetacin is indicated for conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, post-traumatic or post-operative pain, and other inflammatory disorders.

It works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins, substances involved in inflammation, pain, and fever.

The medication is taken orally, usually in the form of capsules or tablets, and the dosage is adjusted based on the severity of symptoms and the patient's response. In some cases, it may be used as suppositories to minimize gastrointestinal irritation.

Common side effects include gastrointestinal disturbances such as nausea, abdominal pain, diarrhea, or constipation. Rarely, more severe reactions such as gastric ulcers, gastrointestinal bleeding, allergic reactions, or kidney impairment may occur.

Acemetacin should be used with caution in patients with a history of gastric ulcers, renal insufficiency, hypertension, or cardiovascular diseases. It is also important to avoid concurrent use with other NSAIDs or anticoagulants, as this may increase the risk of bleeding.