Dose adjustment in renal impairment
Dose adjustment may be needed in kidney disease.
Leaflet ZOMEN PLUS 30mg / 12.5mg film-coated tablets
- Product code:
- W59961001
- Quantity:
- 14
- Indicated for:
- hypertension
- Route of administration:
- oral
- Substance:
- zofenopril + hydrochlorothiazide (ACE inhibitor + diuretic)
- ATC
- C09BA15 — Cardiovascular system | Ace inhibitors, combinations | Ace inhibitors and diuretics
Precautions:
Contraindicated during pregnancy
Do not use this medicine during pregnancy.
Photosensitivity
Avoid excessive exposure to sunlight or UV radiation.
Hypotension / fall risk
May lower blood pressure and increase the risk of falls.
Major drug interactions
This medicine may have important interactions with other medicines.
Requires periodic laboratory tests
Periodic laboratory tests may be required during treatment.
Electrolyte disturbances
This medicine may change blood electrolyte levels.
The combination of zofenopril and hydrochlorothiazide is used for the treatment of essential hypertension (high blood pressure). It combines an angiotensin-converting enzyme (ACE) inhibitor – zofenopril – with a thiazide diuretic – hydrochlorothiazide – to lower blood pressure through complementary mechanisms.
Zofenopril works by inhibiting the angiotensin-converting enzyme, leading to blood vessel dilation and reduced peripheral vascular resistance. This helps lower blood pressure and reduce the workload on the heart.
- Hydrochlorothiazide is a diuretic that increases the excretion of sodium and water by the kidneys, reducing blood volume and, consequently, blood pressure.
This combination is indicated for patients whose blood pressure is not adequately controlled with zofenopril or hydrochlorothiazide alone. The medication is taken orally, usually once daily, and the dose is adjusted based on the patient’s response.
Common side effects include dizziness, headache, fatigue, dry cough (associated with zofenopril), and electrolyte imbalances (such as hypokalemia, associated with hydrochlorothiazide). In rare cases, more serious reactions such as angioedema or kidney dysfunction may occur. Regular monitoring of kidney function, electrolyte levels, and blood pressure is essential during treatment.
Zofenopril works by inhibiting the angiotensin-converting enzyme, leading to blood vessel dilation and reduced peripheral vascular resistance. This helps lower blood pressure and reduce the workload on the heart.
- Hydrochlorothiazide is a diuretic that increases the excretion of sodium and water by the kidneys, reducing blood volume and, consequently, blood pressure.
This combination is indicated for patients whose blood pressure is not adequately controlled with zofenopril or hydrochlorothiazide alone. The medication is taken orally, usually once daily, and the dose is adjusted based on the patient’s response.
Common side effects include dizziness, headache, fatigue, dry cough (associated with zofenopril), and electrolyte imbalances (such as hypokalemia, associated with hydrochlorothiazide). In rare cases, more serious reactions such as angioedema or kidney dysfunction may occur. Regular monitoring of kidney function, electrolyte levels, and blood pressure is essential during treatment.
General data about ZOMEN PLUS 30mg / 12.5mg
- Substance:
- zofenopril + hydrochlorothiazide
- Date of latest medicines list:
- 01-06-2026
- Product code:
- W59961001
- Concentration:
- 30mg / 12.5mg
- Pharmaceutical form:
- film-coated tablets
- Quantity:
- 14
- Product type:
- Original
- Price:
- 33.45 RON
- Prescription status:
- P-6L — Medicines dispensed with a medical prescription that is not retained by the pharmacy and may be renewed; the prescription may be used for 6 months from the date of issue.