ZOMEN PLUS 30mg / 12.5mg film-coated tablets medication leaflet

C09BA15 • zofenopril + hydrochlorothiazide • Cardiovascular system | Ace inhibitors, combinations | Ace inhibitors and diuretics

The combination of zofenopril and hydrochlorothiazide is used for the treatment of essential hypertension (high blood pressure). It combines an angiotensin-converting enzyme (ACE) inhibitor – zofenopril – with a thiazide diuretic – hydrochlorothiazide – to lower blood pressure through complementary mechanisms.

- Zofenopril works by inhibiting the angiotensin-converting enzyme, leading to blood vessel dilation and reduced peripheral vascular resistance. This helps lower blood pressure and reduce the workload on the heart.
- Hydrochlorothiazide is a diuretic that increases the excretion of sodium and water by the kidneys, reducing blood volume and, consequently, blood pressure.

This combination is indicated for patients whose blood pressure is not adequately controlled with zofenopril or hydrochlorothiazide alone. The medication is taken orally, usually once daily, and the dose is adjusted based on the patient’s response.

Common side effects include dizziness, headache, fatigue, dry cough (associated with zofenopril), and electrolyte imbalances (such as hypokalemia, associated with hydrochlorothiazide). In rare cases, more serious reactions such as angioedema or kidney dysfunction may occur. Regular monitoring of kidney function, electrolyte levels, and blood pressure is essential during treatment.