Leaflet VABADIN 40mg film-coated tablets


Indicated for: dyslipidemia

Route of administration: oral

Substance: simvastatin (statin lipid-lowering agent)

ATC: C10AA01 (Cardiovascular system | Lipid modifying agents, plain | Hmg coa reductase inhibitors)

Precautions:
Avoid grapefruit
Avoid grapefruit

Avoid grapefruit and grapefruit juice.

Hepatotoxicity
Hepatotoxicity

This medicine may affect the liver.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Myopathy / rhabdomyolysis
Myopathy / rhabdomyolysis

Seek medical advice if unexplained muscle pain occurs.

Requires periodic laboratory tests
Requires periodic laboratory tests

Periodic laboratory tests may be required during treatment.

Pregnancy warning
Pregnancy warning

Use during pregnancy only on medical advice.

Simvastatin is a medication used to lower cholesterol and triglyceride levels in the blood, and it is indicated for the prevention of cardiovascular diseases such as heart attack and stroke. It belongs to the class of statins, which work by inhibiting the enzyme HMG-CoA reductase, responsible for cholesterol production in the liver.

Simvastatin is taken orally, usually once daily in the evening, as cholesterol synthesis is more active at night. It is used in combination with a healthy diet, exercise, and other cholesterol-lowering measures.

Common side effects include headaches, nausea, constipation, mild muscle pain, and fatigue. In rare cases, it may cause more serious reactions, such as rhabdomyolysis (a severe condition involving muscle tissue breakdown), liver dysfunction, or elevated liver enzyme levels.

Simvastatin is contraindicated in individuals with active liver disease, pregnant or breastfeeding women, and those taking certain medications that may interact with it (such as some antifungals or antibiotics). It is important for patients to follow their doctor's recommendations and undergo regular blood tests to monitor liver function and cholesterol levels.

General data about VABADIN 40mg

  • Substance: simvastatin
  • Date of last drug list: 01-07-2013
  • Commercial code: W43910003
  • Concentration: 40mg
  • Pharmaceutical form: film-coated tablets
  • Quantity: 56
  • Product type: generic
  • Prescription restrictions: P-6L - Medicines prescription that isn't retained in the pharmacy (can be renewed); the prescription can be used for 6 months from the moment of release.

Concentrations available for simvastatin

  • 10mg
  • 20mg
  • 30mg
  • 40mg
  • 5mg
  • 80mg