Take on an empty stomach
Take this medicine on an empty stomach.
Medicine information QUADRIXAM 10mg / 2.5mg / 10mg / 5mg capsules
- Product code:
- W72014001
- Quantity:
- 30
- Indicated for:
- hypertension in adults already controlled with the same four substances at equivalent doses; substitution treatment
- Route of administration:
- oral
- Substance:
- perindopril + indapamide + amlodipine + bisoprolol (ACE inhibitor+thiazide-like diuretic+calcium channel blocker+beta blocker)
- ATC
- C09BX06 — Cardiovascular system | Ace inhibitors, combinations | Ace inhibitors, other combinations
Perindopril + indapamide + amlodipine + bisoprolol treats high blood pressure in selected adults. It can replace the same components taken separately or be prescribed for resistant hypertension inadequately controlled with the first three. It is not an initial treatment. It relaxes blood vessels, increases salt and water excretion and slows the heart rate.
It is taken by mouth, usually as one capsule in the morning before breakfast, at the prescribed strength. The clinician chooses doses and monitors blood pressure, pulse, kidney function and electrolytes. Do not stop abruptly: suddenly withdrawing bisoprolol can worsen heart problems. Changes may require separate components under supervision.
Dizziness, fatigue, dry cough, swollen ankles, slow pulse or low blood pressure can occur. Sodium, potassium and kidney function may change. Stand up slowly if dizzy and report persistent vomiting or diarrhoea, which can worsen dehydration and low blood pressure.
Swelling of the face, tongue or throat with breathing difficulty requires emergency help. Fainting or a very slow pulse needs prompt assessment. Report pregnancy, kidney problems and asthma; the combination is unsuitable in pregnancy and certain kidney or heart conditions. Do not add potassium supplements or anti-inflammatory medicines such as ibuprofen without approval.
It is taken by mouth, usually as one capsule in the morning before breakfast, at the prescribed strength. The clinician chooses doses and monitors blood pressure, pulse, kidney function and electrolytes. Do not stop abruptly: suddenly withdrawing bisoprolol can worsen heart problems. Changes may require separate components under supervision.
Dizziness, fatigue, dry cough, swollen ankles, slow pulse or low blood pressure can occur. Sodium, potassium and kidney function may change. Stand up slowly if dizzy and report persistent vomiting or diarrhoea, which can worsen dehydration and low blood pressure.
Swelling of the face, tongue or throat with breathing difficulty requires emergency help. Fainting or a very slow pulse needs prompt assessment. Report pregnancy, kidney problems and asthma; the combination is unsuitable in pregnancy and certain kidney or heart conditions. Do not add potassium supplements or anti-inflammatory medicines such as ibuprofen without approval.
General data about QUADRIXAM 10mg / 2.5mg / 10mg / 5mg
- Substance:
- perindopril + indapamide + amlodipine + bisoprolol
- Date of latest medicines list:
- 01-08-2026
- Product code:
- W72014001
- Strength:
- 10mg / 2.5mg / 10mg / 5mg
- Pharmaceutical form:
- capsules
- Quantity:
- 30
- Product type:
- Generic medicine
- Prescription status:
- P-6L — Medicines dispensed with a medical prescription that is not retained by the pharmacy and may be renewed; the prescription may be used for 6 months from the date of issue.
Strengths available for perindopril + indapamide + amlodipine + bisoprolol
- 10mg/2.5mg/10mg/5mg
- 10mg/2.5mg/5mg/5mg
- 5mg/1.25mg/5mg/5mg
Official documents
Warnings:
Driving impairment
This medicine may affect your ability to drive or use machines.
Dose adjustment in renal impairment
Dose adjustment may be needed in kidney disease.
Dizziness / vertigo
This medicine may cause dizziness or vertigo.
Glaucoma warning
Use caution if you have glaucoma or increased eye pressure.
General warning
Read the package leaflet before use.
Contraindicated during pregnancy
Do not use this medicine during pregnancy.
Avoid grapefruit
Avoid grapefruit and grapefruit juice.
Photosensitivity
Avoid excessive exposure to sunlight or UV radiation.
Hypotension / fall risk
May lower blood pressure and increase the risk of falls.
Major drug interactions
This medicine may have important interactions with other medicines.
Requires periodic laboratory tests
Periodic laboratory tests may be required during treatment.
Breastfeeding warning
Use during breastfeeding only on medical advice.
Pediatric warning
Use in children only as recommended in the leaflet or by a doctor.
Elderly warning
Older people may have an increased risk of side effects.
Cardiac risk / QT prolongation / arrhythmias
This medicine may increase the risk of heart rhythm disturbances.
Teratogenic / fetal risk
This medicine may affect fetal development.
Withdrawal / do not stop abruptly
Do not stop treatment abruptly without medical advice.
Electrolyte disturbances
This medicine may change blood electrolyte levels.