Leaflet ONCASPAR 750U / ml powder for solution for injection / infusion

Indicated for: cancer

Route of administration: injectable / infusion

Substance: pegaspargase (antineoplastic agent)

ATC: L01XX24 (Antineoplastic and immunomodulating agents | Other antineoplastic agents)

Precautions:
Fertility warning
Fertility warning

This medicine may affect fertility.

Dose adjustment in hepatic impairment
Dose adjustment in hepatic impairment

Dose adjustment may be needed in liver disease.

Cytotoxic / special handling
Cytotoxic / special handling

Handle with special care.

Contraception required
Contraception required

Effective contraception is required during treatment.

Contraindicated during breastfeeding
Contraindicated during breastfeeding

Do not use this medicine while breastfeeding.

Contraindicated during pregnancy
Contraindicated during pregnancy

Do not use this medicine during pregnancy.

Hepatotoxicity
Hepatotoxicity

This medicine may affect the liver.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Myelosuppression / agranulocytosis
Myelosuppression / agranulocytosis

This medicine may lower blood cell counts.

Additional monitoring
Additional monitoring

This medicine is subject to additional monitoring.

Requires periodic laboratory tests
Requires periodic laboratory tests

Periodic laboratory tests may be required during treatment.

Severe skin reactions
Severe skin reactions

Stop taking the medicine and seek urgent medical help if a severe rash occurs.

Pegaspargase is an antineoplastic agent used in the treatment of acute lymphoblastic leukemia (ALL). It works by degrading asparagine, an amino acid essential for the growth of leukemic cells, thereby inhibiting their proliferation.

The medication is administered intravenously or intramuscularly, as directed by a doctor, usually as part of a combination chemotherapy regimen. It is important for patients to follow the treatment regimen and undergo regular tests to monitor the therapy's effects.

Patients should be aware of potential side effects, such as allergic reactions, pancreatitis, or coagulation disorders. It is important to inform the doctor of any unusual symptoms.

Common side effects include allergic reactions, elevated liver enzymes, and coagulation disorders. In rare cases, severe reactions such as acute pancreatitis or thrombosis may occur. Patients should be informed of these risks before use.

General data about ONCASPAR 750U / ml

  • Substance: pegaspargase
  • Date of latest medicines list: 01-06-2026
  • Product code: W66172001
  • Concentration: 750U / ml
  • Pharmaceutical form: powder for solution for injection / infusion
  • Quantity: 1
  • Product type: Original
  • Price: 8303.23 RON
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: LES LABORATOIRES SERVIER INDUSTRIE - FRANTA
  • Holder: LES LABORATOIRES SERVIER - FRANTA
  • Number: 1070/2016/02
  • Shelf life: 2 years

Pharmaceutical forms available for pegaspargase

PDF icon EMA leaflet
Published: 29/01/2016
Updated: 07/05/2026

Compensation lists for ONCASPAR 750U / ml Servier

NHP 3 (C2) - NHP oncology

Price

Copayment

Patient

8303.23 RON

8303.23 RON

0.00 RON