Leaflet KLION-D 100mg / 100mg vaginal tablets

Indicated for: bacterial infections

Route of administration: vaginal

Substance: metronidazole + miconazole (nitroimidazole antimicrobial + azole antifungal)

ATC: G01AF20 (Genito urinary system and sex hormones | Antiinfectives and antiseptics, excl. combinations with corticosteroids | Imidazole derivatives)

Precautions:
Dose adjustment in hepatic impairment
Dose adjustment in hepatic impairment

Dose adjustment may be needed in liver disease.

Dose adjustment in renal impairment
Dose adjustment in renal impairment

Dose adjustment may be needed in kidney disease.

Anaphylaxis
Anaphylaxis

Risk of severe allergic reaction. Seek urgent medical help if serious symptoms occur.

Colitis / severe diarrhea
Colitis / severe diarrhea

Seek medical advice if severe or persistent diarrhea occurs.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Pregnancy warning
Pregnancy warning

Use during pregnancy only on medical advice.

Cardiac risk / QT prolongation / arrhythmias
Cardiac risk / QT prolongation / arrhythmias

This medicine may increase the risk of heart rhythm disturbances.

The combination of metronidazole and miconazole is used for the treatment of mixed vaginal infections caused by anaerobic bacteria and fungi, such as bacterial vaginosis and vaginal candidiasis. Metronidazole acts as an antibacterial agent, while miconazole is an antifungal.

The medication is administered topically, in the form of vaginal suppositories or cream, usually once daily for 7 days. Common side effects include local irritation, itching, and a burning sensation.

This combination is contraindicated in patients with hypersensitivity to any of the components or in pregnant women during the first trimester. Its use also requires caution to prevent imbalances in vaginal flora.

This medication is an effective option for managing mixed vaginal infections, helping to alleviate symptoms and prevent recurrences.

General data about KLION-D 100mg / 100mg

  • Substance: metronidazole + miconazole
  • Date of latest medicines list: 01-06-2026
  • Product code: W54846001
  • Concentration: 100mg / 100mg
  • Pharmaceutical form: vaginal tablets
  • Quantity: 10
  • Product type: Original
  • Price: 28.12 RON
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: GEDEON RICHTER PLC. - UNGARIA
  • Holder: GEDEON RICHTER ROMANIA S.A. - ROMANIA
  • Number: 12934/2020/01
  • Shelf life: 5 years