Driving impairment
This medicine may affect your ability to drive or use machines.
Leaflet BRUFEN PLUS 400mg / 30mg film-coated tablets
- Product code:
- W61948001
- Quantity:
- 30
- Indicated for:
- pain and inflammation
- Route of administration:
- oral
- Substance:
- ibuprofen + codeine (nonsteroidal anti-inflammatory drug + opioid analgesic)
- ATC
- N02AJ08 — Nervous system | Opioids | Opioids in combination with non-opioid analgesics
Precautions:
Dizziness / vertigo
This medicine may cause dizziness or vertigo.
Dependence / abuse
This medicine may cause dependence or be misused.
Respiratory depression
May slow breathing, especially with alcohol or sedatives.
Avoid alcohol
Avoid alcohol during treatment.
Major drug interactions
This medicine may have important interactions with other medicines.
Nephrotoxicity
This medicine may affect the kidneys.
Breastfeeding warning
Use during breastfeeding only on medical advice.
Pregnancy warning
Use during pregnancy only on medical advice.
Elderly warning
Older people may have an increased risk of side effects.
Bleeding risk
This medicine may increase the risk of bleeding.
Withdrawal / do not stop abruptly
Do not stop treatment abruptly without medical advice.
Drowsiness / sedation
This medicine may cause drowsiness or reduced alertness.
Ulcer / gastrointestinal bleeding
This medicine may increase the risk of ulcer or gastrointestinal bleeding.
Ibuprofen and codeine are active ingredients used in combination to treat moderate to severe pain, such as headaches, dental pain, muscle pain, postoperative pain, or pain associated with inflammatory conditions. This combination is effective due to the synergistic effect of the two components, providing fast and long-lasting pain relief.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by inhibiting the synthesis of prostaglandins, substances involved in the inflammatory process. Codeine is a mild opioid that acts on the central nervous system to reduce the perception of pain, enhancing the analgesic effect of ibuprofen.
Although this combination is effective, its use should be approached with caution. Codeine can cause dependency if used long-term or in high doses. It may also cause drowsiness, dizziness, constipation, or nausea. Ibuprofen may cause gastrointestinal side effects, such as stomach irritation, heartburn, or ulcers, especially with long-term use. It is important not to exceed the recommended dose.
This combination is available only by prescription, and its use should be supervised by a doctor. Patients should follow the recommended dosage and avoid alcohol consumption during treatment. If pain persists or worsens, further medical evaluation is necessary.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by inhibiting the synthesis of prostaglandins, substances involved in the inflammatory process. Codeine is a mild opioid that acts on the central nervous system to reduce the perception of pain, enhancing the analgesic effect of ibuprofen.
Although this combination is effective, its use should be approached with caution. Codeine can cause dependency if used long-term or in high doses. It may also cause drowsiness, dizziness, constipation, or nausea. Ibuprofen may cause gastrointestinal side effects, such as stomach irritation, heartburn, or ulcers, especially with long-term use. It is important not to exceed the recommended dose.
This combination is available only by prescription, and its use should be supervised by a doctor. Patients should follow the recommended dosage and avoid alcohol consumption during treatment. If pain persists or worsens, further medical evaluation is necessary.
General data about BRUFEN PLUS 400mg / 30mg
- Substance:
- ibuprofen + codeine
- Date of latest medicines list:
- 01-06-2026
- Product code:
- W61948001
- Concentration:
- 400mg / 30mg
- Pharmaceutical form:
- film-coated tablets
- Quantity:
- 30
- Product type:
- Generic medicine
- Price:
- 35.47 RON
- Prescription status:
- TAB3 — Medicines dispensed with a special medical prescription for psychotropic substances, green in color.
Concentrations available for ibuprofen + codeine
- 200mg+12.80mg
- 200mg/12.8mg
- 400mg/30mg
Compensation lists for BRUFEN PLUS 400mg / 30mg BGP Products
C3 - Sublist C - section C3 (children, pregnant women and postpartum women) with 100% discount from the reference price
- Price
- 35.47 RON
- Copayment
- 35.47 RON
- Patient
- 0.00 RON