Medication leaflets

Active substance

Results for the substance zonisamide

7 results

About this active substance

Zonisamide is an antiepileptic medication used to treat partial seizures, with or without secondary generalization, in patients with epilepsy. It is also sometimes used as an adjunct therapy for other types of epilepsy. Zonisamide works through multiple mechanisms, including blocking sodium and calcium channels, which reduces neuronal excitability and prevents seizures.

Zonisamide is indicated for both adults and children over the age of 6, typically as an adjunct therapy in cases where other antiepileptic drugs do not provide adequate seizure control. The medication is taken orally, and the dose is gradually adjusted to minimize the risk of side effects.

Common side effects include drowsiness, dizziness, nausea, loss of appetite, and weight loss. Rarely, more serious reactions such as metabolic acidosis, kidney stone formation, or severe allergic reactions may occur. Regular monitoring of kidney function and blood bicarbonate levels is important during treatment.

Zonisamide treatment should be administered under the supervision of a specialist, and patients must strictly follow the prescribed dosage. Abrupt discontinuation of the medication can lead to an increase in seizure frequency, so dose reduction should be done gradually, as directed by the doctor.