Active substance
Results for the substance tovorafenib
2 results
About this active substance
Tovorafenib is a targeted medicine used in patients 6 months of age and older with relapsed or refractory pediatric low-grade glioma when the tumour has certain BRAF gene changes. It belongs to the RAF inhibitor class and acts on signalling pathways that drive tumour-cell growth. The aim is to slow down, stop or shrink the tumour.
It is taken by mouth, usually once weekly, as tablets or an oral suspension, exactly as prescribed by the oncology team. The dose may depend on body weight, tolerability and laboratory results. Treatment should be taken consistently; missed doses, vomiting after a dose or troublesome side effects should be discussed with the care team rather than managed independently.
Common side effects include skin rash, dry skin, sensitivity to sunlight, hair colour changes, tiredness, vomiting, nausea, constipation, headache, fever and viral infections. Bleeding, liver test changes, increased muscle enzymes and abnormal blood test results may also occur. Regular check-ups, blood tests and imaging assessments are usually needed during treatment.
Sun protection is important because skin reactions and photosensitivity can be clinically significant. Contact the doctor promptly if unusual bleeding, large bruises, yellowing of the skin or eyes, dark urine, severe rash, persistent fever, dehydration or worsening general condition occur. In children, growth in height may also be monitored throughout treatment.
It is taken by mouth, usually once weekly, as tablets or an oral suspension, exactly as prescribed by the oncology team. The dose may depend on body weight, tolerability and laboratory results. Treatment should be taken consistently; missed doses, vomiting after a dose or troublesome side effects should be discussed with the care team rather than managed independently.
Common side effects include skin rash, dry skin, sensitivity to sunlight, hair colour changes, tiredness, vomiting, nausea, constipation, headache, fever and viral infections. Bleeding, liver test changes, increased muscle enzymes and abnormal blood test results may also occur. Regular check-ups, blood tests and imaging assessments are usually needed during treatment.
Sun protection is important because skin reactions and photosensitivity can be clinically significant. Contact the doctor promptly if unusual bleeding, large bruises, yellowing of the skin or eyes, dark urine, severe rash, persistent fever, dehydration or worsening general condition occur. In children, growth in height may also be monitored throughout treatment.