Medication leaflets

Active substance

Results for the substance tolvaptan

5 results

About this active substance

Tolvaptan is a selective vasopressin V2 receptor antagonist used in the treatment of hyponatremia associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and in the management of autosomal dominant polycystic kidney disease (ADPKD). It works by blocking the effects of vasopressin in the renal collecting ducts, increasing free water excretion and correcting hyponatremia.

Tolvaptan is administered orally, usually once daily, with the dose adjusted based on the patient's response and serum sodium levels. In ADPKD, the treatment aims to slow disease progression and reduce the growth of renal cysts.

Common side effects include thirst, polyuria, dry mouth, and fatigue. In rare cases, severe adverse reactions such as liver function impairment may occur, necessitating regular monitoring of liver enzymes.

Tolvaptan is an innovative therapeutic option for patients with hyponatremia and ADPKD, contributing to improved quality of life and prevention of complications associated with these conditions.