Active substance

Results for the substance tofacitinib

4 results

About this active substance

Tofacitinib is a Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It works by inhibiting the JAK-STAT signaling pathway, reducing inflammation and the abnormal immune response associated with these conditions.

Tofacitinib is administered orally, usually twice daily, with the dose adjusted based on the patient's response and tolerability. It is often used as a second-line therapy for patients who do not respond adequately to conventional treatments.

Common side effects include upper respiratory tract infections, nausea, headache, and increased cholesterol levels. In rare cases, severe adverse reactions such as serious infections, thrombosis, or liver function impairment may occur. Regular monitoring of clinical parameters is essential during treatment.

Tofacitinib is an innovative therapeutic option for patients with chronic inflammatory diseases, contributing to symptom relief and improved quality of life.