Medication leaflets

Active substance

Results for the substance roxadustat

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About this active substance

Roxadustat is a medication used in the treatment of anemia associated with chronic kidney disease (CKD). It is a prolyl hydroxylase inhibitor (HIF-PHI) that stimulates endogenous erythropoietin production and improves iron utilization in the body. Through these mechanisms, roxadustat helps increase red blood cell production and alleviate anemia symptoms.

Roxadustat is administered orally, usually several times a week, and is indicated for both dialysis and non-dialysis patients. It is considered an alternative to traditional treatments with erythropoiesis-stimulating agents (ESAs) and intravenous iron supplements.

Common side effects include nausea, hypertension, diarrhea, and headache. In rare cases, severe adverse reactions such as thrombosis or allergic responses may occur. Regular monitoring of hemoglobin and iron parameters is essential for dose adjustment and prevention of complications.

Roxadustat represents an innovation in the treatment of CKD-associated anemia, offering an effective and well-tolerated oral option for patients.