Rilzabrutinib is a medicine used in adults with persistent or chronic immune thrombocytopenia when previous treatments have not worked well enough. In this condition, the immune system destroys platelets, the blood cells that help stop bleeding. Rilzabrutinib blocks Bruton’s tyrosine kinase, an enzyme involved in immune-cell signalling, and may help raise platelet counts.
It is taken by mouth as tablets, usually twice daily, exactly as prescribed by a haematology specialist. Take it regularly and do not stop it on your own, because platelet counts may fall again and bruising or bleeding can worsen. Your doctor may adjust treatment according to blood tests, side effects, liver function and other medicines.
Common side effects include diarrhoea, nausea, headache, abdominal pain and respiratory infections, including COVID-19. Blood-test changes, liver-enzyme increases or low blood cell counts may also occur. Contact your doctor promptly for fever, repeated infections, yellow skin or eyes, dark urine, widespread bruising, nosebleeds, blood in stools or bleeding that is hard to stop.
Regular blood tests and liver monitoring are important. Tell your healthcare team about all medicines and supplements, especially antifungals, antibiotics, antivirals, acid-reducing medicines and herbal products, because interactions can change rilzabrutinib levels. People who can become pregnant should discuss effective contraception, and pregnancy should be reported immediately.