Active substance
Results for the substance pretomanid
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About this active substance
Pretomanid is an antibiotic used only with other medicines for certain forms of treatment-resistant pulmonary tuberculosis. It acts against Mycobacterium tuberculosis and helps kill the bacteria when standard regimens are not effective or cannot be tolerated. It is not used alone, for latent tuberculosis or for tuberculosis that is sensitive to standard treatment.
It is taken by mouth, usually once daily with food, as part of a regimen chosen by a tuberculosis specialist, for example with bedaquiline and linezolid. Taking every medicine exactly as prescribed and for the full duration is critical. Missing doses or stopping early can cause treatment failure and make the infection harder to treat because of additional resistance.
Side effects may include nausea, vomiting, headache, rash, tiredness, weight loss, liver problems or abnormal blood tests. Some important effects may come from the other medicines in the regimen, such as tingling or numbness, vision problems, anaemia or heart rhythm changes. Contact your doctor if you develop yellow skin or eyes, dark urine, abdominal pain, fainting, palpitations or persistent numbness.
Treatment requires close monitoring, including liver tests, blood counts and sometimes electrocardiograms. Avoid alcohol and tell your doctor about all medicines and supplements you use. Women should discuss pregnancy, breastfeeding and contraception before treatment. Pretomanid should be taken only under specialised tuberculosis supervision.
It is taken by mouth, usually once daily with food, as part of a regimen chosen by a tuberculosis specialist, for example with bedaquiline and linezolid. Taking every medicine exactly as prescribed and for the full duration is critical. Missing doses or stopping early can cause treatment failure and make the infection harder to treat because of additional resistance.
Side effects may include nausea, vomiting, headache, rash, tiredness, weight loss, liver problems or abnormal blood tests. Some important effects may come from the other medicines in the regimen, such as tingling or numbness, vision problems, anaemia or heart rhythm changes. Contact your doctor if you develop yellow skin or eyes, dark urine, abdominal pain, fainting, palpitations or persistent numbness.
Treatment requires close monitoring, including liver tests, blood counts and sometimes electrocardiograms. Avoid alcohol and tell your doctor about all medicines and supplements you use. Women should discuss pregnancy, breastfeeding and contraception before treatment. Pretomanid should be taken only under specialised tuberculosis supervision.