Active substance
Results for the substance naldemedine
1 result
About this active substance
Naldemedine is a medicine used in adults to treat constipation caused by opioid pain medicines, usually when laxatives have not worked well enough. Opioids relieve pain but can slow bowel movement; naldemedine mainly blocks this opioid effect in the gut, so it helps restore bowel activity without usually reducing pain control.
It is taken by mouth, generally as one tablet once daily, at about the same time each day, with or without food. Do not change your opioid dose or stop your pain medicine on your own. Tell your doctor or pharmacist about all other medicines you use, especially antibiotics, antifungals, seizure medicines, rifampicin, and herbal products such as St John’s wort.
Common side effects include stomach pain, diarrhoea, nausea, vomiting, and general abdominal discomfort. Seek medical advice if diarrhoea is severe or persistent, or if you develop strong cramps, sweating, chills, anxiety, irritability, or new pain, as these may point to dehydration, opioid withdrawal, or an intestinal problem.
Naldemedine should not be used if bowel blockage is known or suspected and needs caution in people with serious digestive disease. Tell your healthcare team if you are pregnant, breastfeeding, have significant liver disease, or have ongoing abdominal pain. Treatment should be monitored to improve bowel function safely.
It is taken by mouth, generally as one tablet once daily, at about the same time each day, with or without food. Do not change your opioid dose or stop your pain medicine on your own. Tell your doctor or pharmacist about all other medicines you use, especially antibiotics, antifungals, seizure medicines, rifampicin, and herbal products such as St John’s wort.
Common side effects include stomach pain, diarrhoea, nausea, vomiting, and general abdominal discomfort. Seek medical advice if diarrhoea is severe or persistent, or if you develop strong cramps, sweating, chills, anxiety, irritability, or new pain, as these may point to dehydration, opioid withdrawal, or an intestinal problem.
Naldemedine should not be used if bowel blockage is known or suspected and needs caution in people with serious digestive disease. Tell your healthcare team if you are pregnant, breastfeeding, have significant liver disease, or have ongoing abdominal pain. Treatment should be monitored to improve bowel function safely.