Active substance
Results for the substance ertugliflozin metformin
2 results
About this active substance
The combination of ertugliflozin and metformin is used for the treatment of type 2 diabetes mellitus, particularly in patients who cannot control their blood sugar levels through diet and exercise alone. This combination helps lower blood glucose levels through complementary mechanisms.
- Ertugliflozin is an SGLT2 (sodium-glucose co-transporter 2) inhibitor that works by increasing glucose excretion through the urine, thereby lowering blood sugar levels and providing additional benefits such as weight loss and blood pressure reduction.
- Metformin is a biguanide that decreases glucose production in the liver, improves insulin sensitivity, and reduces glucose absorption from the digestive tract.
This combination is taken orally, usually twice daily, with meals to reduce the risk of gastrointestinal side effects associated with metformin.
Common side effects include nausea, diarrhea, genital infections (especially in women), urinary tract infections, excessive thirst, and frequent urination. In rare cases, diabetic ketoacidosis, lactic acidosis (associated with metformin), or dehydration may occur.
Patients should strictly follow their doctor’s instructions, regularly monitor their blood sugar levels, and maintain adequate hydration. The combination is not recommended for patients with severe renal impairment, liver failure, or a high risk of diabetic ketoacidosis.
- Ertugliflozin is an SGLT2 (sodium-glucose co-transporter 2) inhibitor that works by increasing glucose excretion through the urine, thereby lowering blood sugar levels and providing additional benefits such as weight loss and blood pressure reduction.
- Metformin is a biguanide that decreases glucose production in the liver, improves insulin sensitivity, and reduces glucose absorption from the digestive tract.
This combination is taken orally, usually twice daily, with meals to reduce the risk of gastrointestinal side effects associated with metformin.
Common side effects include nausea, diarrhea, genital infections (especially in women), urinary tract infections, excessive thirst, and frequent urination. In rare cases, diabetic ketoacidosis, lactic acidosis (associated with metformin), or dehydration may occur.
Patients should strictly follow their doctor’s instructions, regularly monitor their blood sugar levels, and maintain adequate hydration. The combination is not recommended for patients with severe renal impairment, liver failure, or a high risk of diabetic ketoacidosis.