Active substance
Results for the substance difelikefalin
1 result
About this active substance
Difelikefalin is a medicine for moderate to severe itching associated with chronic kidney disease in adults receiving haemodialysis. Kidney-related itching can disturb sleep, mood and daily life. The medicine acts on kappa opioid receptors, mainly outside the brain, to help reduce itch signals.
It is given by injection, usually in the dialysis centre at the end of a haemodialysis session. The dose depends on body weight and dialysis schedule. Patients do not normally inject it at home. Tell the dialysis team if you miss a session, change dialysis days or receive an extra treatment, because timing may need adjustment.
Side effects may include sleepiness, dizziness, headache, tingling, nausea, diarrhoea or mental status changes such as confusion. Report marked drowsiness, disorientation, unsteadiness, falls or unusual symptoms after the injection. Until you know how it affects you, be cautious with driving, machinery or tasks requiring alertness.
Difelikefalin relieves itching but does not cure kidney disease. Your clinician may also check other causes such as dry skin, high phosphate, allergies or other medicines. Continue dialysis and kidney-related treatments as advised. Tell your doctor about all medicines you take, especially sedatives or drugs causing dizziness, and ask for advice if pregnant or breastfeeding.
It is given by injection, usually in the dialysis centre at the end of a haemodialysis session. The dose depends on body weight and dialysis schedule. Patients do not normally inject it at home. Tell the dialysis team if you miss a session, change dialysis days or receive an extra treatment, because timing may need adjustment.
Side effects may include sleepiness, dizziness, headache, tingling, nausea, diarrhoea or mental status changes such as confusion. Report marked drowsiness, disorientation, unsteadiness, falls or unusual symptoms after the injection. Until you know how it affects you, be cautious with driving, machinery or tasks requiring alertness.
Difelikefalin relieves itching but does not cure kidney disease. Your clinician may also check other causes such as dry skin, high phosphate, allergies or other medicines. Continue dialysis and kidney-related treatments as advised. Tell your doctor about all medicines you take, especially sedatives or drugs causing dizziness, and ask for advice if pregnant or breastfeeding.