Active substance
Results for the substance belimumab
4 results
About this active substance
Belimumab is a biological medicine used in patients with active systemic lupus erythematosus despite standard treatment, and in selected cases of active lupus nephritis. It is a monoclonal antibody that blocks a protein called BLyS/BAFF, which is involved in the survival of B lymphocytes. By doing this, it may reduce disease activity and flares.
It is given by intravenous infusion or subcutaneous injection, depending on the prescribed form. Treatment is decided by a rheumatologist or nephrologist and is used together with other lupus medicines, not as emergency treatment for severe flares. The effect develops gradually, and patients should keep recommended visits and blood tests.
Side effects may include respiratory infections, nausea, diarrhoea, fever, injection-site pain, headache, insomnia or infusion reactions. Severe allergic reactions can occur, including several hours after administration. Because it affects the immune system, it may increase the risk of some infections and requires caution in patients with active infection.
Contact a doctor urgently if breathing difficulty, facial swelling, severe rash, persistent fever, significant cough, pain when urinating, worsening depression or thoughts of self-harm occur. Tell the doctor about vaccines, pregnancy, breastfeeding, chronic infections and all immunosuppressants used. Live vaccines are usually avoided during treatment.
It is given by intravenous infusion or subcutaneous injection, depending on the prescribed form. Treatment is decided by a rheumatologist or nephrologist and is used together with other lupus medicines, not as emergency treatment for severe flares. The effect develops gradually, and patients should keep recommended visits and blood tests.
Side effects may include respiratory infections, nausea, diarrhoea, fever, injection-site pain, headache, insomnia or infusion reactions. Severe allergic reactions can occur, including several hours after administration. Because it affects the immune system, it may increase the risk of some infections and requires caution in patients with active infection.
Contact a doctor urgently if breathing difficulty, facial swelling, severe rash, persistent fever, significant cough, pain when urinating, worsening depression or thoughts of self-harm occur. Tell the doctor about vaccines, pregnancy, breastfeeding, chronic infections and all immunosuppressants used. Live vaccines are usually avoided during treatment.