Medication leaflets

Active substance

Results for the substance aprotinin

4 results

About this active substance

Aprotinin is a protease inhibitor used to reduce blood loss during major surgical procedures, such as cardiac surgery with cardiopulmonary bypass. It works by inhibiting proteolytic enzymes such as trypsin, plasmin, and kallikrein, thereby preventing fibrin degradation and reducing the risk of excessive bleeding.

Aprotinin is administered intravenously, usually during surgery, according to a specific protocol. It is often used in patients at high risk of bleeding or requiring massive transfusions.

Side effects may include allergic reactions, renal failure, or thrombotic events. Its use requires careful monitoring, especially in patients with pre-existing conditions.

Aprotinin is a valuable medication in managing intraoperative blood loss, helping to reduce the need for transfusions and improve surgical outcomes.