Leaflet VIMOVO 500mg / 20mg modified release tablets

Indicated for: pain and inflammation

Route of administration: oral

Substance: naproxen + esomeprazole (nonsteroidal anti-inflammatory drug + proton pump inhibitor)

ATC: M01AE52 (Musculo-skeletal system | Antiinflammatory and antirheumatic products, non-steroids | Propionic acid derivatives)

Precautions:
Photosensitivity
Photosensitivity

Avoid excessive exposure to sunlight or UV radiation.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Nephrotoxicity
Nephrotoxicity

This medicine may affect the kidneys.

Pregnancy warning
Pregnancy warning

Use during pregnancy only on medical advice.

Bleeding risk
Bleeding risk

This medicine may increase the risk of bleeding.

Ulcer / gastrointestinal bleeding
Ulcer / gastrointestinal bleeding

This medicine may increase the risk of ulcer or gastrointestinal bleeding.

Naproxen + esomeprazole is a combination medication used to treat pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, while reducing the risk of gastrointestinal complications caused by nonsteroidal anti-inflammatory drugs (NSAIDs).

- Naproxen is an NSAID that reduces pain, inflammation, and fever by inhibiting prostaglandin production.
- Esomeprazole is a proton pump inhibitor (PPI) that decreases stomach acid production, protecting the stomach lining from irritation and ulcers caused by naproxen.

This combination is particularly indicated for patients at higher risk of gastric ulcers or gastrointestinal bleeding.

Side effects may include nausea, stomach pain, diarrhea, dizziness, or, in rare cases, allergic reactions. Long-term use may increase the risk of cardiovascular events (due to naproxen) or gastrointestinal infections (due to reduced stomach acid). It is important to take this medication as prescribed by a doctor.

VIMOVO 500mg/20mg modified release tablets ASTRAZENECA, naproxen+esomeprazole

General data about VIMOVO 500mg / 20mg

  • Substance: naproxen + esomeprazole
  • Date of latest medicines list: 01-06-2026
  • Product code: W57029003
  • Concentration: 500mg / 20mg
  • Pharmaceutical form: modified release tablets
  • Quantity: 30
  • Product type: Original
  • Price: 66.35 RON
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: ASTRAZENECA AB - SUEDIA
  • Holder: ASTRA ZENECA AB - SUEDIA
  • Number: 9516/2016/03
  • Shelf life: 2 years

Other substances similar to naproxen + esomeprazole

Compensation lists for VIMOVO 500mg / 20mg AstraZeneca

B - Sublist B with 50% discount from the reference price

Price

Copayment

Patient

66.35 RON

28.43 RON

37.92 RON