L01CE01 • topotecan • Antineoplastic and immunomodulating agents | Plant alkaloids and other natural products | Topoisomerase 1 (TOP1) inhibitors
Topotecan is an antineoplastic agent from the class of topoisomerase I inhibitors, used in the treatment of recurrent ovarian cancer, small cell lung cancer, and other types of cancer. It works by inhibiting the enzyme topoisomerase I, which is essential for DNA replication, thereby causing tumor cell death.
Topotecan is administered intravenously or orally, usually in treatment cycles, with the dose adjusted based on the patient's body weight and tolerability. It is often used in combination with other chemotherapeutic agents to enhance treatment efficacy.
Common side effects include neutropenia, anemia, nausea, vomiting, diarrhea, and fatigue. In rare cases, severe adverse reactions such as serious infections or pulmonary toxicity may occur. Careful monitoring of hematological parameters and the patient's overall condition is essential during treatment.
Topotecan is an important therapeutic option for patients with advanced cancer, contributing to disease control and prolonged survival.
Substance: topotecan
Date of last drug list: 01-06-2025
Commercial code: W65809001
Concentration: 1mg / ml
Pharmaceutical form: perfusive solution concentrate
Quantity: 1
Product type: generic
Price: 95.96 RON
Prescription restrictions: P-RF - Medicines prescription that is retained in the pharmacy (not renewable).
Manufacturer: ACCORD HEALTHCARE POLSKA SP. Z.O.O. - POLONIA
Holder: ACCORD HEALTHCARE POLSKA SP. Z.O.O. - POLONIA
Number: 11187/2018/01
Shelf life: 3 years-after packing for marketing; dupa dilutie- it is used immediately