Fertility warning
This medicine may affect fertility.
Leaflet TOPOTECAN ACCORD 1mg / ml concentrate for solution for infusion
- Product code:
- W65809003
- Quantity:
- 1
- Indicated for:
- ovarian cancer; small cell lung cancer
- Route of administration:
- infusion
- Substance:
- topotecan (topoisomerase inhibitor)
- ATC
- L01CE01 — Antineoplastic and immunomodulating agents | Plant alkaloids and other natural products | Topoisomerase 1 (TOP1) inhibitors
Precautions:
Cytotoxic / special handling
Handle with special care.
Contraception required
Effective contraception is required during treatment.
Contraindicated during breastfeeding
Do not use this medicine while breastfeeding.
Contraindicated during pregnancy
Do not use this medicine during pregnancy.
Hepatotoxicity
This medicine may affect the liver.
Major drug interactions
This medicine may have important interactions with other medicines.
Myelosuppression / agranulocytosis
This medicine may lower blood cell counts.
Additional monitoring
This medicine is subject to additional monitoring.
Requires periodic laboratory tests
Periodic laboratory tests may be required during treatment.
Severe skin reactions
Stop taking the medicine and seek urgent medical help if a severe rash occurs.
Topotecan is an antineoplastic agent from the class of topoisomerase I inhibitors, used in the treatment of recurrent ovarian cancer, small cell lung cancer, and other types of cancer. It works by inhibiting the enzyme topoisomerase I, which is essential for DNA replication, thereby causing tumor cell death.
Topotecan is administered intravenously or orally, usually in treatment cycles, with the dose adjusted based on the patient's body weight and tolerability. It is often used in combination with other chemotherapeutic agents to enhance treatment efficacy.
Common side effects include neutropenia, anemia, nausea, vomiting, diarrhea, and fatigue. In rare cases, severe adverse reactions such as serious infections or pulmonary toxicity may occur. Careful monitoring of hematological parameters and the patient's overall condition is essential during treatment.
Topotecan is an important therapeutic option for patients with advanced cancer, contributing to disease control and prolonged survival.
Topotecan is administered intravenously or orally, usually in treatment cycles, with the dose adjusted based on the patient's body weight and tolerability. It is often used in combination with other chemotherapeutic agents to enhance treatment efficacy.
Common side effects include neutropenia, anemia, nausea, vomiting, diarrhea, and fatigue. In rare cases, severe adverse reactions such as serious infections or pulmonary toxicity may occur. Careful monitoring of hematological parameters and the patient's overall condition is essential during treatment.
Topotecan is an important therapeutic option for patients with advanced cancer, contributing to disease control and prolonged survival.
General data about TOPOTECAN ACCORD 1mg / ml
- Substance:
- topotecan
- Date of latest medicines list:
- 01-06-2026
- Product code:
- W65809003
- Concentration:
- 1mg / ml
- Pharmaceutical form:
- concentrate for solution for infusion
- Quantity:
- 1
- Product type:
- Generic medicine
- Price:
- 340.17 RON
- Prescription status:
- P-RF — Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.
Pharmaceutical forms available for topotecan
Concentrations available for topotecan
- 0.25mg
- 1mg
- 1mg/1ml
- 1mg/ml
- 4mg
- 4mg/4ml
- 500mg