Dose adjustment in renal impairment
Dose adjustment may be needed in kidney disease.
Leaflet TOBI 300mg / 5ml solution for inhalation by nebuliser
- Product code:
- W68686002
- Quantity:
- 56
- Indicated for:
- bacterial infections
- Route of administration:
- inhalation
- Substance:
- tobramycin (aminoglycoside antibiotic)
- ATC
- J01GB01 — Antiinfectives for systemic use | Aminoglycoside antibacterials | Other aminoglycosides
Precautions:
Anaphylaxis
Risk of severe allergic reaction. Seek urgent medical help if serious symptoms occur.
Colitis / severe diarrhea
Seek medical advice if severe or persistent diarrhea occurs.
Nephrotoxicity
This medicine may affect the kidneys.
Ototoxicity
This medicine may affect hearing or balance.
Pregnancy warning
Use during pregnancy only on medical advice.
Tobramycin is an aminoglycoside antibiotic used to treat severe bacterial infections caused by Gram-negative bacteria, such as Pseudomonas aeruginosa. It is commonly used for respiratory infections, skin infections, urinary tract infections, and eye infections. Tobramycin works by inhibiting bacterial protein synthesis, leading to bacterial destruction.
The medication is available in various forms, including injectable solutions, eye drops, and inhalation solutions (for pulmonary infections, such as those associated with cystic fibrosis). The dosage and route of administration depend on the type and severity of the infection.
Common side effects include local irritation (for topical use), nausea, vomiting, and skin rashes. When administered systemically, tobramycin can cause serious adverse effects, such as ototoxicity (hearing damage), nephrotoxicity (kidney damage), and neurotoxicity. For this reason, careful monitoring of kidney function and hearing is required during treatment. Tobramycin is contraindicated in patients with hypersensitivity to aminoglycosides.
The medication is available in various forms, including injectable solutions, eye drops, and inhalation solutions (for pulmonary infections, such as those associated with cystic fibrosis). The dosage and route of administration depend on the type and severity of the infection.
Common side effects include local irritation (for topical use), nausea, vomiting, and skin rashes. When administered systemically, tobramycin can cause serious adverse effects, such as ototoxicity (hearing damage), nephrotoxicity (kidney damage), and neurotoxicity. For this reason, careful monitoring of kidney function and hearing is required during treatment. Tobramycin is contraindicated in patients with hypersensitivity to aminoglycosides.
General data about TOBI 300mg / 5ml
- Substance:
- tobramycin
- Date of latest medicines list:
- 01-05-2022
- Product code:
- W68686002
- Concentration:
- 300mg / 5ml
- Pharmaceutical form:
- solution for inhalation by nebuliser
- Packing volume:
- 5ml
- Product type:
- Original
- Prescription status:
- P-RF — Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.
Pharmaceutical forms available for tobramycin
Concentrations available for tobramycin
- 0.3%
- 300mg
- 300mg/5ml
- 3mg/g
- 3mg/ml
- 40mg/ml