Leaflet SOLPADEINE EXTRACAFF 500mg/65mg 500mg / 12.8mg / 30mg effervescent tablets


Indicated for: cold and flu symptoms

Substance: paracetamol + codeine + caffeine (analgesic and antipyretic + opioid analgesic + xanthine stimulant)

ATC: N02BE51 (Nervous system | Other analgesics and antipyretics | Anilides)

Paracetamol, codeine, and caffeine are active ingredients used in combination to treat moderate to severe pain, such as headaches, migraines, dental pain, or muscle pain. This combination is effective due to the synergistic effect of the three components, providing fast and long-lasting pain relief.

Paracetamol is an analgesic and antipyretic that reduces pain and fever, being well-tolerated by most patients. Codeine is a mild opioid that acts on the central nervous system to reduce the perception of pain, enhancing the analgesic effect of paracetamol. Caffeine acts as a stimulant and improves the absorption of analgesics, increasing the treatment's efficiency.

Although this combination is effective, its use should be approached with caution. Codeine can cause dependency if used long-term or in high doses. It may also cause drowsiness, dizziness, or constipation. Caffeine may lead to insomnia, agitation, or palpitations, especially in sensitive individuals. It is important not to exceed the recommended dose to avoid adverse effects, including liver toxicity associated with paracetamol.

This combination is available only by prescription, and its use should be supervised by a doctor. Patients should follow the recommended dosage and avoid alcohol consumption during treatment. If the pain persists or worsens, further medical evaluation is necessary.

General data about SOLPADEINE EXTRACAFF 500mg/65mg 500mg / 12.8mg / 30mg

  • Substance: paracetamol + codeine + caffeine
  • Date of last drug list: 01-01-2023
  • Commercial code: W69310001
  • Concentration: 500mg / 12.8mg / 30mg
  • Pharmaceutical form: effervescent tablets
  • Quantity: 4
  • Product type: generic
  • Prescription restrictions: OTC - Over the Counter = medicines that do not require a prescription.

Marketing authorisation

  • Manufacturer: FAMAR A.V.E. ANTHOUSSA PLANT - GRECIA
  • Holder: PERRIGO ROMANIA S.R.L. - ROMANIA
  • Number: 14782/2022/01
  • Shelf life: 48 months

Pharmaceutical forms available for paracetamol + codeine + caffeine

Concentrations available for paracetamol + codeine + caffeine

  • 500mg/12.8mg/30mg
  • 500mg/8mg/30mg