Leaflet SINTROM 4mg tablets

Indicated for: prevention and treatment of thromboembolism

Route of administration: oral

Substance: acenocoumarol (anticoagulant)

ATC: B01AA07 (Blood and blood forming organs | Antithrombotic agents | Vitamin K antagonists)

Acenocoumarol is an anticoagulant medication from the coumarin class, used for the prevention and treatment of thrombosis and embolism. It is indicated for conditions such as deep vein thrombosis, pulmonary embolism, atrial fibrillation, and the prevention of thromboembolic complications in patients with prosthetic heart valves.

Acenocoumarol works by inhibiting the synthesis of vitamin K-dependent clotting factors (factors II, VII, IX, and X), thereby reducing the blood's ability to form clots.

The dosage is individually adjusted based on regular monitoring of the INR (International Normalized Ratio) to maintain a balance between preventing clot formation and minimizing the risk of bleeding.

Common side effects include an increased risk of bleeding (e.g., nosebleeds, gum bleeding, or gastrointestinal bleeding), easy bruising, and, in rare cases, skin necrosis. Patients should avoid excessive consumption of foods rich in vitamin K (such as spinach, broccoli, or cabbage), as these can reduce the medication's effectiveness.

Acenocoumarol requires careful monitoring and frequent dose adjustments. Patients should inform their doctor about any other medications or supplements they are taking, as interactions can affect blood clotting.