Leaflet SINERDOL ISO 300mg+150mg 300mcg / 150mcg capsules

Indicated for: bacterial infections

Route of administration: oral

Substance: rifampicin + isoniazid (anti-tuberculosis agents)

ATC: J04AM02 (Antiinfectives for systemic use | Drugs for treatment of tuberculosis | Combinations of drugs for treatment of tuberculosis)

Precautions:
Hepatotoxicity
Hepatotoxicity

This medicine may affect the liver.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Requires periodic laboratory tests
Requires periodic laboratory tests

Periodic laboratory tests may be required during treatment.

Pregnancy warning
Pregnancy warning

Use during pregnancy only on medical advice.

The combination of rifampicin and isoniazid is used for the treatment and prevention of tuberculosis (TB). Rifampicin works by inhibiting bacterial RNA synthesis, while isoniazid interferes with the synthesis of the cell wall of Mycobacterium tuberculosis.

The medication is taken orally, as directed by a doctor, usually once daily. It is important for patients to follow the treatment regimen to prevent the development of bacterial resistance.

Patients should be aware of potential side effects, such as nausea, fatigue, or liver-related symptoms like jaundice. It is important to inform the doctor of any unusual symptoms.

Common side effects include nausea, fatigue, and liver-related symptoms. In rare cases, severe reactions such as hepatotoxicity or allergic reactions may occur. Patients should be informed of these risks before starting treatment.

General data about SINERDOL ISO 300mg+150mg 300mcg / 150mcg

  • Substance: rifampicin + isoniazid
  • Date of latest medicines list: 01-06-2026
  • Product code: W14071002
  • Concentration: 300mcg / 150mcg
  • Pharmaceutical form: capsules
  • Quantity: 1000
  • Product type: Generic medicine
  • Price: 1251.47 RON
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: ANTIBIOTICE SA - ROMANIA
  • Holder: ANTIBIOTICE SA - ROMANIA
  • Number: 13454/2020/02
  • Shelf life: 3 years

Pharmaceutical forms available for rifampicin + isoniazid

Concentrations available for rifampicin + isoniazid

  • 150mg/100mg
  • 300mcg/150mcg
  • 300mg/150mg

Compensation lists for SINERDOL ISO 300mg+150mg 300mcg / 150mcg Antibiotice

NHP 1.A (C2) - People with HIV/AIDS and post-exposure treatment

Price

Copayment

Patient

1251.47 RON

1251.47 RON

0.00 RON

NHP 1.B (C2) - Tuberculosis

Price

Copayment

Patient

1251.47 RON

1251.47 RON

0.00 RON