ROGLUTEN 250mg tablets medication leaflet

L02BG01 • aminoglutethimide • Antineoplastic and immunomodulating agents | Hormone antagonists and related agents | Aromatase inhibitors

Aminoglutethimide is a medication primarily used in the treatment of certain types of cancer, such as breast cancer and adrenal cancer, as well as in Cushing's syndrome. It works by inhibiting the synthesis of steroid hormones, including cortisol, estrogens, and androgens, through the blockade of the aromatase enzyme and other enzymes involved in steroid production.

Aminoglutethimide is administered orally, usually in tablet form, with the dosage adjusted based on the patient's response and the severity of the condition. The treatment requires careful monitoring, as it can affect adrenal gland function and lead to adrenal insufficiency.

Common side effects include drowsiness, dizziness, nausea, skin rashes, and muscle weakness. In rare cases, severe adverse reactions such as hepatotoxicity or bone marrow suppression may occur.

Patients taking aminoglutethimide should undergo regular monitoring for liver and adrenal function. Additionally, the medication may interact with other hormonal treatments, necessitating dose adjustments. Aminoglutethimide is an important therapeutic option for managing hormone-dependent conditions, but its use must be carefully supervised by a specialist physician.