Leaflet HOLOXAN 2g powder for solution for infusion

Indicated for: cancer

Route of administration: infusion

Substance: ifosfamide (alkylating antineoplastic agent)

ATC: L01AA06 (Antineoplastic and immunomodulating agents | Alkylating agents | Nitrogen mustard analogues)

Precautions:
Fertility warning
Fertility warning

This medicine may affect fertility.

Dose adjustment in hepatic impairment
Dose adjustment in hepatic impairment

Dose adjustment may be needed in liver disease.

Cytotoxic / special handling
Cytotoxic / special handling

Handle with special care.

Contraception required
Contraception required

Effective contraception is required during treatment.

Contraindicated during breastfeeding
Contraindicated during breastfeeding

Do not use this medicine while breastfeeding.

Contraindicated during pregnancy
Contraindicated during pregnancy

Do not use this medicine during pregnancy.

Hepatotoxicity
Hepatotoxicity

This medicine may affect the liver.

Major drug interactions
Major drug interactions

This medicine may have important interactions with other medicines.

Myelosuppression / agranulocytosis
Myelosuppression / agranulocytosis

This medicine may lower blood cell counts.

Additional monitoring
Additional monitoring

This medicine is subject to additional monitoring.

Requires periodic laboratory tests
Requires periodic laboratory tests

Periodic laboratory tests may be required during treatment.

Severe skin reactions
Severe skin reactions

Stop taking the medicine and seek urgent medical help if a severe rash occurs.

Ifosfamide is a chemotherapy medication used to treat various types of cancer, including sarcomas, lymphomas, and testicular cancer. It belongs to the class of alkylating agents and works by interfering with the DNA of cancer cells, thereby inhibiting their growth and division.

The medication is administered via intravenous infusion under the supervision of an oncologist.

Side effects may include nausea, vomiting, hair loss, decreased blood cell counts, or hemorrhagic cystitis. In rare cases, severe allergic reactions or kidney dysfunction may occur.

Patients should be closely monitored during treatment and inform their doctor about any other medications they are taking. Pregnant or breastfeeding women should not use this medication.

General data about HOLOXAN 2g

  • Substance: ifosfamide
  • Date of latest medicines list: 01-07-2013
  • Product code: W12496001
  • Concentration: 2g
  • Pharmaceutical form: powder for solution for infusion
  • Quantity: 1
  • Product type: Original
  • Prescription status: S - Medicines dispensed with a restricted medical prescription, reserved for use in certain specialized fields.

Concentrations available for ifosfamide

  • 1g
  • 2g
  • 500mg