Indicated for: smoking cessation; nicotine dependence
Substance: cytisinicline (nicotinic acetylcholine receptor partial agonist)
ATC: N07BA04 (Nervous system | Drugs used in addictive disorders | Drugs used in nicotine dependence)
Cytisinicline, also known as cytisine in some countries, is a medicine used to support smoking cessation. It acts on nicotinic receptors in the brain, partly stimulating the same receptor type that nicotine uses. This can reduce cigarette craving and withdrawal symptoms while making smoking less rewarding.
Treatment works best when it is combined with a clear quit plan, behavioural support and strategies to avoid smoking triggers. The exact schedule depends on the product and country, so patients should follow the instructions given by their doctor or pharmacist. Do not double a missed dose and do not extend the course without medical advice.
Before using cytisinicline, tell your doctor if you are pregnant, breastfeeding, have heart disease, high blood pressure, a previous stroke, stomach ulcer, kidney disease or a mental health condition. Also mention all other medicines. Continuing to smoke during treatment may increase unpleasant effects, and nicotine itself remains harmful to the heart and blood vessels.
Possible side effects include nausea, dry mouth, headache, dizziness, irritability, insomnia, unusual dreams, mild palpitations and stomach discomfort. Seek medical help if you develop chest pain, irregular heartbeat, fainting, allergic symptoms, severe anxiety, depression or thoughts of self-harm. The medicine is a tool to help quitting, but follow-up and motivation remain essential.