DUOPLAVIN 75mg / 75mg film-coated tablets medication leaflet

B01AC30 • clopidogrel + acetylsalicylic acid • Blood and blood forming organs | Antithrombotic agents | Platelet aggregation inhibitors excl. heparin

Clopidogrel and acetylsalicylic acid (aspirin) are used in combination to prevent blood clots in patients at high risk of cardiovascular events, such as myocardial infarction, stroke, or unstable angina. This combination is commonly used in the treatment of acute coronary syndromes and after procedures such as coronary angioplasty with stent implantation.

Clopidogrel is an antiplatelet agent that inhibits platelet aggregation by blocking P2Y12 receptors on the surface of platelets. Acetylsalicylic acid is also an antiplatelet agent that works by inhibiting cyclooxygenase (COX-1), thereby reducing the production of thromboxane A2, a substance that promotes platelet aggregation. Together, these medications provide a synergistic antiplatelet effect, reducing the risk of blood clot formation.

While this combination is effective, its use requires caution. The most common side effects include an increased risk of bleeding, such as gastrointestinal bleeding or nosebleeds. Other side effects may include abdominal pain, nausea, or allergic reactions. It is important for patients to inform their doctor of any history of bleeding, gastric ulcers, or other conditions that may increase the risk of complications.

This combination should be used as directed by a doctor, and patients should adhere to the prescribed dosage. It is important to avoid concurrent use with other medications that increase the risk of bleeding, such as anticoagulants or other nonsteroidal anti-inflammatory drugs (NSAIDs). If signs of excessive bleeding or other severe side effects occur, immediate medical attention is necessary.