Leaflet CERVUGID 200mg / 500mg / 660000UI / 15mg ovules

Indicated for: mixed vaginal infections

Substance: chloramphenicol + metronidazole + nystatin + hydrocortisone (antibacterial antibiotic + nitroimidazole antimicrobial + antifungal + glucocorticoid)

ATC: G01BAN1 (Genito urinary system and sex hormones | Antiinfectives/antiseptics in combination with corticosteroids | Antibiotics and corticosteroids)

Chloramphenicol, metronidazole, nystatin, and hydrocortisone are used together in certain medications to treat complex infections involving bacteria, fungi, and inflammation. This combination is particularly indicated for skin, vaginal, or rectal infections where antimicrobial, antifungal, and anti-inflammatory actions are required.

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis, effective against gram-positive and gram-negative bacteria. Metronidazole is an antimicrobial and antiprotozoal agent that acts against anaerobic bacteria and protozoa. Nystatin is an antifungal effective against fungal infections, particularly Candida albicans. Hydrocortisone is a corticosteroid with anti-inflammatory and antipruritic properties, reducing inflammation, swelling, and itching.

While this combination is effective, its use requires caution. Chloramphenicol may cause rare side effects, such as hypersensitivity or bone marrow aplasia. Metronidazole may cause nausea, dizziness, or allergic reactions. Nystatin is generally well-tolerated but may cause local irritation. Hydrocortisone, if used long-term, can lead to skin thinning, secondary infections, or suppression of the hypothalamic-pituitary-adrenal axis.

This combination should be used as directed by a doctor, and the duration of treatment should be limited to reduce the risk of side effects. It is important to avoid long-term use or application over large areas of the skin. If severe side effects or persistent symptoms occur, immediate medical attention is necessary.