Major drug interactions
This medicine may have important interactions with other medicines.
Leaflet CENTRALGIN 500mg tablets
- Product code:
- W65928001
- Quantity:
- 20
- Indicated for:
- pain and inflammation
- Route of administration:
- oral
- Substance:
- metamizole sodium (nonsteroidal anti-inflammatory drug)
- ATC
- N02BB02 — Nervous system | Other analgesics and antipyretics | Pyrazolones
Precautions:
Nephrotoxicity
This medicine may affect the kidneys.
Pregnancy warning
Use during pregnancy only on medical advice.
Bleeding risk
This medicine may increase the risk of bleeding.
Ulcer / gastrointestinal bleeding
This medicine may increase the risk of ulcer or gastrointestinal bleeding.
Metamizole sodium, also known as Dipyrone, is a medication used to relieve moderate to severe pain and to reduce fever that does not respond to other treatments. It is an analgesic and antipyretic from the pyrazolone class, with antispasmodic properties, making it useful for treating renal or biliary colic.
Metamizole works by inhibiting the synthesis of prostaglandins, substances involved in inflammation and pain perception. It is available in tablet form, injectable solutions, or suppositories and is used for both short-term treatments and acute situations.
Side effects may include allergic reactions, low blood pressure (especially with injectable forms), and, in rare cases, agranulocytosis (a severe decrease in white blood cells). For this reason, long-term use is discouraged, and it should be taken only as prescribed by a doctor. It is contraindicated during pregnancy, breastfeeding, and in patients with hematological disorders.
Metamizole works by inhibiting the synthesis of prostaglandins, substances involved in inflammation and pain perception. It is available in tablet form, injectable solutions, or suppositories and is used for both short-term treatments and acute situations.
Side effects may include allergic reactions, low blood pressure (especially with injectable forms), and, in rare cases, agranulocytosis (a severe decrease in white blood cells). For this reason, long-term use is discouraged, and it should be taken only as prescribed by a doctor. It is contraindicated during pregnancy, breastfeeding, and in patients with hematological disorders.
General data about CENTRALGIN 500mg
- Substance:
- metamizole sodium
- Date of latest medicines list:
- 01-06-2026
- Product code:
- W65928001
- Concentration:
- 500mg
- Pharmaceutical form:
- tablets
- Quantity:
- 20
- Product type:
- Generic medicine
- Price:
- 11.18 RON
- Prescription status:
- P-RF — Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.
Pharmaceutical forms available for metamizole sodium
Concentrations available for metamizole sodium
- 1000mg
- 300mg
- 500mg
- 500mg/ml
Combinations with other substances
- metamizole sodium + caffeine + drotaverine
- metamizole sodium + pitofenone hydrochloride + fenpipramide bromomethylate
- metamizole sodium + drotaverine + caffeine
- metamizole sodium + pitofenone hydrochloride + bromomethyl fenpipramide
- metamizole sodium + pitofenone hydrochloride + fenpiverinium bromide
Compensation lists for CENTRALGIN 500mg Sintofarm
C3 - Sublist C - section C3 (children, pregnant women and postpartum women) with 100% discount from the reference price
- Price
- 11.18 RON
- Copayment
- 9.29 RON
- Patient
- 1.89 RON