ATSIMUTIN 25mg tablets medication leaflet

L04AX01 • azathioprine • Antineoplastic and immunomodulating agents | Immunosuppressants | Other immunosuppressants

Azathioprine is an immunosuppressive agent used in the treatment of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel diseases (Crohn's disease and ulcerative colitis). It is also used to prevent organ rejection following transplants, particularly kidney transplants.

Azathioprine works by inhibiting purine synthesis, reducing the proliferation of T and B lymphocytes, and suppressing the immune response. It is administered orally or intravenously, with the dose adjusted based on body weight and patient response.

Common side effects include nausea, vomiting, diarrhea, and bone marrow suppression, which can lead to anemia, leukopenia, and thrombocytopenia. In rare cases, severe adverse reactions such as hepatotoxicity, pancreatitis, or an increased risk of infections and malignancies may occur. Regular monitoring of hematological and hepatic parameters is essential during treatment.

Azathioprine is an effective therapeutic option for managing autoimmune diseases and preventing organ rejection, contributing to improved quality of life for patients.