Leaflet ARPARIAL 25mg / 7.5mg film-coated tablets


Indicated for: heart failure

Substance: metoprolol + ivabradine (beta blocker + cardiac If-current inhibitor)

ATC: C07FX05 (Cardiovascular system | Beta blocking agents, other combinations)

The combination of metoprolol and ivabradine is used for the treatment of chronic heart failure and stable angina pectoris. This combination combines a beta-blocker (metoprolol) and an If channel inhibitor (ivabradine) to reduce heart rate and improve cardiac function.

Metoprolol helps reduce the heart's oxygen demand, while ivabradine lowers the heart rate without affecting myocardial contractility. This leads to better heart perfusion and reduced angina symptoms.

The medication is administered as directed by a doctor, and the dose should be adjusted based on the patient's condition. It is important to monitor heart rate during treatment to avoid severe bradycardia.

Side effects may include dizziness, fatigue, or temporary visual disturbances. Patients with severe bradycardia, severe liver impairment, or allergies to any of the medication's components should avoid its use.

General data about ARPARIAL 25mg / 7.5mg

  • Substance: metoprolol + ivabradine
  • Commercial code: W61988001
  • Concentration: 25mg / 7.5mg
  • Pharmaceutical form: film-coated tablets
  • Quantity: 14
  • Product type: generic
  • Prescription restrictions: P-6L - Medicines prescription that isn't retained in the pharmacy (can be renewed); the prescription can be used for 6 months from the moment of release.

Marketing authorisation

  • Manufacturer: LES LABORATOIRES SERVIER INDUSTRIE - FRANTA
  • Holder: EGIS PHARMACEUTICALS PLC - UNGARIA
  • Number: 13049/2020/01
  • Shelf life: 30 months

Concentrations available for metoprolol + ivabradine

  • 25mg/5mg
  • 25mg/7.5mg
  • 50mg/5mg
  • 50mg/7.5mg