Indicated for: menopausal symptoms
Substance: estradiol + drospirenone (estrogen + progestogen)
ATC: G03FA17 (Genito urinary system and sex hormones | Progestogens and estrogens in combination | Progestogens and estrogens, fixed combinations)
Estradiol and drospirenone are used together in hormone replacement therapy (HRT) for postmenopausal women. This combination helps alleviate menopausal symptoms and prevent osteoporosis in women at high risk.
Estradiol, an estrogen, replaces natural hormones that decline during menopause, reducing symptoms such as hot flashes, night sweats, vaginal dryness, and irritability. Drospirenone, a synthetic progestin, protects the uterine lining from excessive estrogen effects, preventing endometrial hyperplasia.
Drospirenone also has an antimineralocorticoid effect, which helps reduce water retention and bloating, common symptoms during hormonal therapy. This can improve the overall tolerability of the treatment.
Side effects may include headaches, nausea, breast tenderness, mood changes, or weight gain. In rare cases, more serious reactions such as blood clots, high blood pressure, or liver problems may occur, making regular medical monitoring essential.
Patients should strictly follow their doctor’s recommendations, and long-term use should be periodically evaluated to minimize risks and maximize treatment benefits.