Leaflet AMBRISENTAN ZENTIVA 5mg film-coated tablets

Indicated for: pulmonary arterial hypertension

Route of administration: oral

Substance: ambrisentan (vasodilator)

ATC: C02KX02 (Cardiovascular system | Other antihypertensives | Antihypertensives for pulmonary arterial hypertension)

Precautions:
Dizziness / vertigo
Dizziness / vertigo

This medicine may cause dizziness or vertigo.

Hypotension / fall risk
Hypotension / fall risk

May lower blood pressure and increase the risk of falls.

Ambrisentan is a medication used in the treatment of pulmonary arterial hypertension (PAH), a condition characterized by increased pressure in the pulmonary arteries, leading to shortness of breath, fatigue, and other symptoms. It belongs to a class of drugs called endothelin receptor antagonists and works by blocking the effects of endothelin-1, a substance that causes blood vessel constriction and increased blood pressure.

Ambrisentan is taken orally, usually once daily, with the dosage adjusted based on the patient's response to treatment. It is often used in combination with other PAH medications, such as phosphodiesterase-5 inhibitors or prostanoids.

Side effects may include headaches, fluid retention, nasal congestion, and anemia. In rare cases, more severe adverse effects, such as liver function impairment, may occur.

Patients taking ambrisentan should undergo regular monitoring for liver function and hemoglobin levels. Additionally, the medication is contraindicated during pregnancy as it can cause birth defects. Ambrisentan is an important option for managing PAH, improving patients' quality of life.

General data about AMBRISENTAN ZENTIVA 5mg

  • Substance: ambrisentan
  • Date of latest medicines list: 01-04-2021
  • Product code: W67458001
  • Concentration: 5mg
  • Pharmaceutical form: film-coated tablets
  • Quantity: 10
  • Product type: Generic medicine
  • Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.

Marketing authorisation

  • Manufacturer: GENEPHARM S.A. - GRECIA
  • Holder: ZENIVA, K.S. - REP. CEHA
  • Number: 13712/2021/01
  • Shelf life: 3 years

Concentrations available for ambrisentan

  • 10mg
  • 5mg