TRACRIUM 25mg / 2.5ml injectible solution medication leaflet

M03AC04 • atracurium • Musculo-skeletal system | Muscle relaxants, peripherally acting agents | Other quaternary ammonium compounds

Atracurium is a non-depolarizing neuromuscular blocking agent used in general anesthesia to facilitate tracheal intubation and provide muscle relaxation during surgical procedures. It works by blocking nicotinic receptors at the neuromuscular junction, inhibiting the transmission of nerve impulses to the muscles.

Atracurium is administered intravenously and has a rapid onset of action, typically within 2-3 minutes, with a duration of action of approximately 20-35 minutes. It is metabolized through a chemical process called Hofmann elimination, which is independent of liver or kidney function, making it suitable for patients with hepatic or renal impairment.

Common side effects include hypotension, skin flushing, and injection site reactions. In rare cases, severe adverse reactions such as bronchospasm or anaphylactic reactions may occur. Administration should be performed by a qualified professional with careful monitoring of respiratory and neuromuscular function.

Atracurium is a safe and effective option for muscle relaxation in the context of general anesthesia, contributing to the safety and success of surgical procedures.