Leaflet RETROVIR 100mg capsules
Indicated for: HIV-1 infection
Route of administration: oral
Substance: zidovudine (nucleoside/nucleotide reverse transcriptase inhibitor)
ATC: J05AF01 (Antiinfectives for systemic use | Direct acting antivirals | Nucleoside and nucleotide reverse transcriptase inhibitors)
Use during breastfeeding only on medical advice.
Use during pregnancy only on medical advice.
Zidovudine is an antiretroviral medication used in the treatment of human immunodeficiency virus (HIV-1) infection. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and was one of the first drugs approved for HIV treatment. Zidovudine is used in combination with other antiretroviral drugs to reduce viral load, slow disease progression, and prevent mother-to-child transmission of the virus during pregnancy and childbirth.
The mechanism of action of zidovudine involves inhibiting reverse transcriptase, an enzyme essential for HIV replication. Zidovudine is converted into its active form (zidovudine triphosphate) inside infected cells, where it integrates into the forming viral DNA chain, thereby blocking viral replication.
Zidovudine is administered orally in the form of tablets or syrup, and in severe cases, it can be given intravenously. It is used in both adults and children, with the dosage adjusted based on body weight and the patient’s overall condition. It is also used prophylactically to reduce the risk of HIV transmission in cases of accidental exposure (post-exposure prophylaxis).
While effective, zidovudine can cause side effects. The most common include nausea, vomiting, headache, fatigue, and anemia. In rare cases, more serious reactions such as myelosuppression (reduction in blood cell counts), liver damage, or lactic acidosis may occur. Regular monitoring of patients is essential to detect and manage potential complications.
General data about RETROVIR 100mg
- Substance: zidovudine
- Date of latest medicines list: 01-06-2026
- Product code: W65176002
- Concentration: 100mg
- Pharmaceutical form: capsules
- Quantity: 100
- Product type: Original
- Price: 492.40 RON
- Prescription status: P-RF - Medicines dispensed with a medical prescription that is retained by the pharmacy and cannot be renewed.
Pharmaceutical forms available for zidovudine
Concentrations available for zidovudine
- 1%
- 100mg
- 10mg/ml
Combinations with other substances
Compensation lists for RETROVIR 100mg ViiV
NHP 1.A (C2) - People with HIV/AIDS and post-exposure treatment
Price
Copayment
Patient
492.40 RON
492.40 RON
0.00 RON