MDT-COMBI 300mg+100mg+50mg+100mg capsules+tablets medication leaflet

J04BA51 • rifampicin + clofazimine + dapsone • Antiinfectives for systemic use | Drugs for treatment of lepra

Rifampicin + clofazimine + dapsone is an antibiotic combination used to treat leprosy, or Hansen’s disease. Leprosy is caused by Mycobacterium leprae and affects the skin and peripheral nerves. Combination treatment kills the bacteria, reduces infectiousness and prevents resistance. When taken correctly, it can cure the disease and reduce disability.

The exact regimen depends on the type of leprosy and is set by the doctor or public health programme. Some doses may be supervised, others taken daily at home for months. It is essential not to miss doses and to finish the full course, even if skin patches or numbness improve. Treatment may not reverse established nerve damage.

Side effects may include nausea, abdominal pain, rash, itching, anaemia, tiredness or liver problems. Rifampicin can turn urine, tears and sweat orange-red, which can stain soft contact lenses. Clofazimine can darken the skin and body fluids, sometimes for months after treatment. Dapsone can rarely cause severe skin reactions, low haemoglobin or breathing problems, especially in G6PD deficiency.

Contact your doctor if you develop fever, yellow skin or eyes, very dark urine, marked paleness, shortness of breath, blistering rash, new nerve pain or loss of sensation. Tell your healthcare team about all other medicines, because rifampicin has many interactions and can reduce the effectiveness of hormonal contraceptives. Care of skin, eyes, hands and feet helps prevent complications.