Leaflet COMBIGAN 2mg / 5mg / ml ophthalmic drops solution


Indicated for: glaucoma; ocular hypertension

Substance: brimonidine + timolol (glaucoma agent + beta blocker)

ATC: S01ED51 (Sensory organs | Antiglaucoma preparations and miotics | Beta blocking agents)

The combination of brimonidinum and timololum is used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brimonidine is an alpha-adrenergic receptor agonist that decreases the production of intraocular fluid, while timolol is a beta-blocker that lowers intraocular pressure by reducing fluid production.

The medication is administered as eye drops, usually twice daily, as directed by a doctor. It is important for patients to strictly follow the treatment regimen to prevent vision deterioration.

Common side effects include a burning or stinging sensation in the eyes, dry eyes, headache, and fatigue. In rare cases, allergic reactions or breathing difficulties may occur.

This combination is not recommended for pregnant or breastfeeding women unless the benefits outweigh the risks. Patients should inform their doctor about any other conditions or medications being used to avoid drug interactions.

General data about COMBIGAN 2mg / 5mg / ml

  • Substance: brimonidine + timolol
  • Date of last drug list: 01-12-2022
  • Commercial code: W69265001
  • Concentration: 2mg / 5mg / ml
  • Pharmaceutical form: ophthalmic drops solution
  • Quantity: 1
  • Product type: original
  • Prescription restrictions: P-RF - Medicines prescription that is retained in the pharmacy (not renewable).

Marketing authorisation

  • Manufacturer: ALLERGAN PHARMACEUTICALS IRELAND - IRLANDA
  • Holder: ABBVIE LIMITED - IRLANDA
  • Number: 11340/2019/01
  • Shelf life: 21 months-after packing for marketing;after the first opening-28 days