BIOFEN EXTRA 400mg / 325mg tablets medication leaflet

M01AE51 • ibuprofen + paracetamol • Musculo-skeletal system | Antiinflammatory and antirheumatic products, non-steroids | Propionic acid derivatives

Ibuprofen and paracetamol are two active ingredients commonly used in combination to treat mild to moderate pain and fever. This combination is effective in relieving headaches, muscle pain, dental pain, menstrual pain, and other types of discomfort, providing complementary analgesic and antipyretic effects.

Paracetamol is an analgesic and antipyretic that reduces pain and fever, being well-tolerated by most patients. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by inhibiting the synthesis of prostaglandins, substances involved in the inflammatory process. Together, these substances provide more effective pain and inflammation relief than using either one alone.

Although this combination is effective, its use should be approached with caution. Ibuprofen may cause gastrointestinal side effects, such as stomach irritation, heartburn, or ulcers, especially with long-term use. Paracetamol, if overused, can harm the liver. It is important for patients to follow the recommended dosage and avoid alcohol consumption during treatment.

This combination is available over the counter, but patients should adhere to usage instructions and avoid long-term use without consulting a doctor. If pain or fever persists for more than a few days, medical advice is necessary to identify the cause and adjust the treatment.