AVANDIA 4mg tablets medication leaflet

A10BG02 • rosiglitazone • Alimentary tract and metabolism | Blood glucose lowering drugs, excl. insulins | Thiazolidinediones

Rosiglitazone is a medication used to treat type 2 diabetes. It belongs to the thiazolidinedione class and works by increasing the sensitivity of cells to insulin, thereby helping to control blood glucose levels. It is typically used in combination with other antidiabetic medications or alongside an appropriate diet and exercise regimen.

Rosiglitazone acts by activating PPAR-gamma receptors (peroxisome proliferator-activated receptors), which regulate glucose and lipid metabolism. This improves glucose utilization in peripheral tissues and reduces glucose production in the liver.

Common side effects include weight gain, fluid retention, and edema. In rare cases, it may increase the risk of heart failure or bone fractures, which is why its use is carefully monitored. Rosiglitazone is contraindicated in patients with severe heart failure or active liver disease.

Treatment with rosiglitazone should be administered under the supervision of a doctor, and patients should be regularly monitored to assess the therapy's effectiveness and safety. It is important for patients to follow dietary and exercise recommendations to achieve the best outcomes.