ARPLEXAM 5mg / 5mg / 1.25mg tablets medication leaflet

C09BX01 • perindopril + amlodipine + indapamide • Cardiovascular system | Ace inhibitors, combinations | Ace inhibitors, other combinations

The combination of perindopril, amlodipine, and indapamide is used to treat essential hypertension (high blood pressure) in patients requiring combination therapy. This combination helps lower blood pressure and prevent cardiovascular complications such as heart attack, stroke, or heart failure.

Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that relaxes blood vessels and lowers blood pressure. Amlodipine is a calcium channel blocker that dilates blood vessels, improving blood flow and reducing blood pressure. Indapamide is a thiazide diuretic that removes excess salt and water from the body, reducing blood volume and, consequently, blood pressure.

This combination is recommended for patients who cannot control their blood pressure with a single medication or a combination of two drugs. Through the synergistic action of the three components, the treatment provides more effective blood pressure control and reduces the risk of cardiovascular complications.

Side effects may include dizziness, headache, swelling (especially in the ankles), nausea, fatigue, or muscle cramps. In rare cases, allergic reactions, severe hypotension, kidney, or liver problems may occur. Regular medical monitoring is essential to adjust the treatment if necessary.

Patients should strictly follow their doctor’s instructions regarding dosage and avoid excessive salt or alcohol consumption. It is also recommended to inform the doctor about other medications being taken or pre-existing conditions, such as kidney or liver impairment.